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KMID : 0614620130620030169
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Korean Journal of Gastroenterology
2013 Volume.62 No. 3 p.169 ~ p.173
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A Rare Case of Free Bowel Perforation Associated with Infliximab Treatment for Stricturing Crohn’s Disease
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Lim Chang-Sup
Moon Won
Park Seon-Ja
Park Moo-In
Kim Hyung-Hun
Kim Jong-Bin
Choi Jeong-Moon
Chang Hee-Kyung
Lee Seung-Hyun
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Abstract
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Crohn’s disease is characterized by chronic transmural inflammation of the bowel and is associated with serious complications, such as bowel strictures, abscesses, fistula formation, and perforation. As neither medical nor surgical therapy provides a cure for Crohn’s disease, the primary goals of therapy are to induce and maintain remission and prevent complications. As a biologic agent, infliximab, a monoclonal antibody to tumor necrosis factor, is indicated for refractory luminal and fistulizing Crohn’s disease that does not respond to other medical therapies or surgery. Infliximab has proven to be very effective for inducing and maintaining remission in Crohn’s disease; however, infliximab treatment has several potential complications. Here, we report a case of free perforation following a therapeutic response after an initial dose of infliximab for Crohn’s disease. This is the first case report describing a free perforation in a Crohn’s disease patient after an initial dose of infliximab.
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KEYWORD
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Crohn’s disease, Stricture, Infliximab, Perforation
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